Background:

This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.

Applications:

ELISA, IHC

Name of antibody:

MDFI

Immunogen:

Fusion protein of human MDFI

Full name:

MyoD family inhibitor

Synonyms:

I-MF; I-mfa

SwissProt:

Q99750

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer and Human colorectal cancer

IHC Recommend dilution:

50-300