Background:

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Applications:

WB

Name of antibody:

MAPT(Phospho-Thr217)

Immunogen:

Peptide sequence around phosphorylation site of threonine 217(L-P-T(p)-P-P) derived from Human Tau.

Full name:

microtubule-associated protein tau

Synonyms:

TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103

SwissProt:

P10636

WB Predicted band size:

79 kDa

WB Positive control:

HepG2 cells lysates

WB Recommended dilution:

500-1000