Background:

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Applications:

WB, IHC

Name of antibody:

MAPT (Phospho-Thr205)

Immunogen:

Synthetic peptide of human MAPT (Phospho-Thr205)

Full name:

microtubule-associated protein tau(Phospho-Thr205)

Synonyms：

TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17

SwissProt:

P10636

IHC positive control:

Rat hippocampal regionfrom a model with Alzheimer’s Disease

IHC Recommend dilution:

50-100

WB Predicted band size:

48 kDa; 62 kDa; 78 kDa

WB Positive control:

Mouse Brain tissue

WB Recommended dilution:

500-1000