Background:

This gene encodes a hydrolase that degrades glycosaminoglycans, including heparan sulfate, dermatan sulfate, and chondroitin-4,6-sulfate. The enzyme forms a homotetramer that is localized to the lysosome. Mutations in this gene result in mucopolysaccharidosis type VII. Alternative splicing results in multiple transcript variants. There are many pseudogenes of this locus in the human genome.

Applications:

ELISA, WB, IHC

Name of antibody:

GUSB

Immunogen:

Fusion protein of human GUSB

Full name:

glucuronidase beta

Synonyms:

BG; MPS7

SwissProt:

P08236

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human cervical cancer

IHC Recommend dilution:

40-200

WB Predicted band size:

75 kDa

WB Positive control:

K562 cell lysate

WB Recommended dilution:

500-2000