Background:

This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found.

Applications:

ELISA, WB, IHC

Name of antibody:

GSR

Immunogen:

Fusion protein of human GSR

Full name:

Glutathione reductase

SwissProt:

P00390

ELISA Recommended dilution:

2000-10000

IHC positive control:

Human cervical cancer and Human ovarian cancer

IHC Recommend dilution:

50-200

WB Predicted band size:

56 kDa

WB Positive control:

Jurkat, Hela and A549 cells

WB Recommended dilution:

1000-5000