Background:

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Applications:

WB

Name of antibody:

MAPT(Ab-717/400)

Immunogen:

Synthesized non-phosphopeptide derived from human Tau around the phosphorylation site of serine 717/400 (V-V-S(p)-G-D).

Full name:

microtubule-associated protein tau

Synonyms：

TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103

SwissProt:

P10636

WB Predicted band size:

79 kDa

WB Positive control:

Rat brain tissue lysate

WB Recommended dilution:

500-3000